Dialysate Potassium, Serum Potassium, Mortality, and Arrhythmia Events in Hemodialysis: Results From the Dialysis Outcomes and Practice Patterns Study (DOPPS).

ABSTRACT:

Background

Sudden death is a leading cause of death in patients on maintenance hemodialysis therapy. During hemodialysis sessions, the gradient between serum and dialysate levels results in rapid electrolyte shifts, which may contribute to arrhythmias and sudden death. Controversies exist about the optimal electrolyte concentration in the dialysate; specifically, it is unclear whether patient outcomes differ among those treated with a dialysate potassium concentration of 3 mEq/L compared to 2 mEq/L.

Study design

Prospective cohort study.

Setting & participants

55,183 patients from 20 countries in the Dialysis Outcomes and Practice Patterns Study (DOPPS) phases 1 to 5 (1996-2015).

Predictor

Dialysate potassium concentration at study entry.

Outcomes

Cox re

SUBMITTER: Karaboyas A 

PROVIDER: S-EPMC5520979 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature