Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring.

ABSTRACT:

Purpose

To investigate whether a more frequent monitoring of the absolute neutrophil counts (ANC) during myelosuppressive chemotherapy, together with model-based predictions, can improve therapy management, compared to the limited clinical monitoring typically applied today.

Methods

Daily ANC in chemotherapy-treated cancer patients were simulated from a previously published population model describing docetaxel-induced myelosuppression. The simulated values were used to generate predictions of the individual ANC time-courses, given the myelosuppression model. The accuracy of the predicted ANC was evaluated under a range of conditions with reduced amount of ANC measurements.

Results

The predictions were most accurate when more data were available for generating the pre

SUBMITTER: Netterberg I 

PROVIDER: S-EPMC5532422 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature