DNA Microarray Analysis of Estrogen Responsive Genes in Ishikawa Cells by Glabridin.

ABSTRACT: Based on a previous study, glabridin displayed a dose-dependent increase in estrogenic activity and cell proliferative activity in Ishikawa cells. However, when treated in combination with 17β-E₂, synergistic estrogenic effect was observed but without the same synergistic increase in cell proliferative effect. This study aimed to identify the estrogen and nonestrogen-regulated activities induced by glabridin and in combination with 17β-E₂ in comparison with 17β-E₂. The results showed that 10 µM glabridin and the combination treatment of 100 nM glabridin with 1 nM 17β-E₂ regulated both the genomic and nongenomic estrogen pathways to possibly provide benefits of estrogens in cardiovascular, circulatory, and vasculature systems. Meanwhile, the combi

SUBMITTER: Melissa PSW 

PROVIDER: S-EPMC5533267 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature