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Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group.


ABSTRACT: The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n=3097) for whom suicidality data were available. Prevalence of suicidal symptoms among major depressive disorder (MDD) cases ranged between 29 and 69% across cohorts. We compared mean subcortical grey matter volumes, lateral ventricle volumes and total intracranial volume (ICV) in MDD patients with suicidal symptoms (N=451) vs healthy controls (N=1996) or MDD patients with no suicidal symptoms (N=650). MDD patients reporting suicidal plans or attempts showed a smaller ICV (P=4.12 × 10-3) or a 2.87% smaller volume compared with controls (Cohen's d=-0.284). In addition, we observed a nonsignificant trend in which MDD cases with suicidal symptoms had smaller subcortical volumes and larger ventricular volumes compared with controls. Finally, no significant differences (P=0.28-0.97) were found between MDD patients with and those without suicidal symptoms for any of the brain volume measures. This is by far the largest neuroimaging meta-analysis of suicidal behaviour in MDD to date. Our results did not replicate previous reports of association between subcortical brain structure and suicidality and highlight the need for collecting better-powered imaging samples and using improved suicidality assessment instruments.

SUBMITTER: Renteria ME 

PROVIDER: S-EPMC5534952 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group.

Rentería M E ME   Schmaal L L   Hibar D P DP   Couvy-Duchesne B B   Strike L T LT   Mills N T NT   de Zubicaray G I GI   McMahon K L KL   Medland S E SE   Gillespie N A NA   Hatton S N SN   Lagopoulos J J   Veltman D J DJ   van der Wee N N   van Erp T G M TGM   Wittfeld K K   Grabe H J HJ   Block A A   Hegenscheid K K   Völzke H H   Veer I M IM   Walter H H   Schnell K K   Schramm E E   Normann C C   Schoepf D D   Konrad C C   Zurowski B B   Godlewska B R BR   Cowen P J PJ   Penninx B W J H BWJH   Jahanshad N N   Thompson P M PM   Wright M J MJ   Martin N G NG   Christensen H H   Hickie I B IB  

Translational psychiatry 20170502 5


The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n=3097) for whom suicidality data were  ...[more]

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