Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death.

ABSTRACT:

Background

Germline mutations in BRCA1/2 and ATM have been associated with prostate cancer (PCa) risk.

Objective

To directly assess whether germline mutations in these three genes distinguish lethal from indolent PCa and whether they confer any effect on age at death.

Design, setting, and participants

A retrospective case-case study of 313 patients who died of PCa and 486 patients with low-risk localized PCa of European, African, and Chinese descent. Germline DNA of each of the 799 patients was sequenced for these three genes.

Outcome measurements and statistical analysis

Mutation carrier rates and their effect on lethal PCa were analyzed using the Fisher's exact test and Cox regression analysis, respectively.

Results and limitations

The combined BRCA1/2

SUBMITTER: Na R 

PROVIDER: S-EPMC5535082 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature