Germline Mutations in ATM and BRCA1/2 Are Associated with Grade Reclassification in Men on Active Surveillance for Prostate Cancer.

ABSTRACT:

Background

Mutations in DNA repair genes are associated with aggressive prostate cancer (PCa).

Objective

To assess whether germline mutations are associated with grade reclassification (GR) in patients undergoing active surveillance (AS).

Design, setting, and participants

Two independent cohorts of PCa patients undergoing AS; 882 and 329 patients from Johns Hopkins and North Shore, respectively.

Outcome measurements and statistical analysis

Germline DNA was sequenced for DNA repair genes, including BRCA1/2 and ATM (three-gene panel). Pathogenicity of mutations was defined according to the American College of Medical Genetics guidelines. Association of mutation carrier status and GR was evaluated by a competing risk analysis.

Results and limitations

Of 12

SUBMITTER: Carter HB 

PROVIDER: S-EPMC6699614 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature