A clinical scoring system to prioritise investigation for tuberculosis among adults attending HIV clinics in South Africa.

ABSTRACT:

Background

The World Health Organization (WHO) recommendation for regular tuberculosis (TB) screening of HIV-positive individuals with Xpert MTB/RIF as the first diagnostic test has major resource implications.

Objective

To develop a diagnostic prediction model for TB, for symptomatic adults attending for routine HIV care, to prioritise TB investigation.

Design

Cohort study exploring a TB testing algorithm.

Setting

HIV clinics, South Africa.

Participants

Representative sample of adult HIV clinic attendees; data from participants reporting ≥1 symptom on the WHO screening tool were split 50:50 to derive, then internally validate, a prediction model.

Outcome

TB, defined as "confirmed" if Xpert MTB/RIF, line probe assay or M. tuberculosis culture were

SUBMITTER: Hanifa Y 

PROVIDER: S-EPMC5542442 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature