Adjuvanting a viral vectored vaccine against pre-erythrocytic malaria.

ABSTRACT: The majority of routinely given vaccines require two or three immunisations for full protective efficacy. Single dose vaccination has long been considered a key solution to improving the global immunisation coverage. Recent infectious disease outbreaks have further highlighted the need for vaccines that can achieve full efficacy after a single administration. Viral vectors are a potent immunisation platform, benefiting from intrinsic immuno-stimulatory features while retaining excellent safety profile through the use of non-replicating viruses. We investigated the scope for enhancing the protective efficacy of a single dose adenovirus-vectored malaria vaccine in a mouse model of malaria by co-administering it with vaccine adjuvants. Out of 11 adjuvants, only two, Abisco^®-100 and

SUBMITTER: Milicic A 

PROVIDER: S-EPMC5544665 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature