Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes?

ABSTRACT:

Context

Genome-wide association studies identified >50 type 1 diabetes (T1D) associated non-human leukocyte antigens (non-HLA) loci.

Objective

The purpose of this study was to assess the contribution of non-HLA single nucleotide polymorphisms (SNPs) to risk of disease progression.

Design and setting

The TrialNet Pathway to Prevention Study follows relatives of T1D patients for development of autoantibodies (Abs) and T1D.

Participants

Using the Immunochip, we analyzed 53 diabetes-associated, non-HLA SNPs in 1016 Ab-positive, at-risk non-Hispanic white relatives.

Main outcome measure

Effect of SNPs on the development of multiple Abs and T1D.

Results

Cox proportional analyses included all substantial non-HLA SNPs, HLA genotypes, relationship to proba

SUBMITTER: Steck AK 

PROVIDER: S-EPMC5546868 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature