Substance P activates Mas-related G protein-coupled receptors to induce itch.

ABSTRACT:

Background

Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas-related G protein-coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin-1.

Objective

Because Mrgprs mediate some aspects of inflammation that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to determine whether itch induced by SP can also be mediated by Mrgprs.

Methods

Genetic and pharmacologic approaches were used to evaluate the contribution of Mrgprs to SP-induced scratching behavior and activation of cultured dorsal root ganglion neurons from mice.

Results

SP-induced scratching behavior and activation of cultured dorsal r

SUBMITTER: Azimi E 

PROVIDER: S-EPMC5546940 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature