Long-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate.

ABSTRACT: Metallic zinc implanted into the abdominal aorta of rats out to 6months has been demonstrated to degrade while avoiding responses commonly associated with the restenosis of vascular implants. However, major questions remain regarding whether a zinc implant would ultimately passivate through the production of stable corrosion products or via a cell mediated fibrous encapsulation process that prevents the diffusion of critical reactants and products at the metal surface. Here, we have conducted clinically relevant long term in vivo studies in order to characterize late stage zinc implant biocorrosion behavior and products to address these critical questions. We found that zinc wires implanted in the murine artery exhibit steady corrosion without local toxicity for up to at least 20months pos

SUBMITTER: Drelich AJ 

PROVIDER: S-EPMC5553077 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature