Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC5556653 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Journal of Cancer 20170703 10
Bladder cancer is a challenging and fatal malignancy and the improvement in prognosis is limited over years. Deep understanding the mechanism of bladder cancer tumorigenesis and progression will help to discover novel and effective treatment strategies. In this study, we identify non-canonical IkB kinase TBK1 is up-regulated in bladder cancer tissue and cell lines. Knockdown of TBK1 markedly inhibits cell proliferation and migration. Inhibition of TBK1 kinase activity by BX795 significantly atte ...[more]