Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer.

ABSTRACT:

Aim

Metabolism and transport play major roles in life-long exposure to endogenous and exogenous carcinogens. We therefore explored associations between polymorphisms in absorption, distribution, metabolism and elimination genes and the risk and prognosis of castration-resistant prostate cancer (CRPC).

Materials & methods

A total of 634 genotypes were tested in 74 patients using the Affymetrix DMETv1.0 platform.

Results

No relation to risk was found. Three SNPs were associated with CRPC prognosis in Caucasians: ABCB11 rs7602171G>A (p = 0.003; n = 30; hazard ratio [HR]: 0.307), GSTP1 rs1799811C>T (p = 0.001; n = 38; HR: 0.254) and SLC5A6 rs1395 (p = 0.004; n = 35; HR: 3.15). Two other polymorphisms among Caucasians were associated with interesting trends: ABCB4 rs230238

SUBMITTER: Sissung TM 

PROVIDER: S-EPMC5558514 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature