Dataset Information
Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer.
Ontology highlight
ABSTRACT: Aim
Metabolism and transport play major roles in life-long exposure to endogenous and exogenous carcinogens. We therefore explored associations between polymorphisms in absorption, distribution, metabolism and elimination genes and the risk and prognosis of castration-resistant prostate cancer (CRPC).Materials & methods
A total of 634 genotypes were tested in 74 patients using the Affymetrix DMETv1.0 platform.Results
No relation to risk was found. Three SNPs were associated with CRPC prognosis in Caucasians: ABCB11 rs7602171G>A (p = 0.003; n = 30; hazard ratio [HR]: 0.307), GSTP1 rs1799811C>T (p = 0.001; n = 38; HR: 0.254) and SLC5A6 rs1395 (p = 0.004; n = 35; HR: 3.15). Two other polymorphisms among Caucasians were associated with interesting trends: ABCB4 rs2302387C>T (p = 0.039) and ABCC5 rs939339A>G (p = 0.018).Conclusion
This exploratory study is the first to show that polymorphisms in several absorption, distribution, metabolism and elimination genes may be associated with CRPC prognosis.
SUBMITTER: Sissung TM
PROVIDER: S-EPMC5558514 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer.
Pharmacogenomics 20161124 18
<h4>Aim</h4>Metabolism and transport play major roles in life-long exposure to endogenous and exogenous carcinogens. We therefore explored associations between polymorphisms in absorption, distribution, metabolism and elimination genes and the risk and prognosis of castration-resistant prostate cancer (CRPC).<h4>Materials & methods</h4>A total of 634 genotypes were tested in 74 patients using the Affymetrix DMETv1.0 platform.<h4>Results</h4>No relation to risk was found. Three SNPs were associat ...[more]