Fifteen Genetic Loci Associated With the Electrocardiographic P Wave.

ABSTRACT:

Background

The P wave on an ECG is a measure of atrial electric function, and its characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave duration and P-wave terminal force traditionally have been used as markers for left atrial enlargement, and both have been associated with increased risk of atrial fibrillation. Here, we explore the genetic basis of P-wave morphology through meta-analysis of genome-wide association study results for P-wave duration and P-wave terminal force from 12 cohort studies.

Methods and results

We included 44 456 individuals, of which 6778 (16%) were of African ancestry. Genotyping, imputation, and genome-wide association study were performed at each study site. Summary-level results were meta-analyzed centrally using in

SUBMITTER: Christophersen IE 

PROVIDER: S-EPMC5567993 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature