Year-round influenza immunisation during pregnancy in Nepal: a phase 4, randomised, placebo-controlled trial.

ABSTRACT:

Background

Influenza immunisation during pregnancy is recommended but not widely implemented in some low-income regions. We assessed the safety and efficacy in mothers and infants of year-round maternal influenza immunisation in Nepal, where influenza viruses circulate throughout the year.

Methods

In this phase 4, randomised, placebo-controlled trial, we enrolled two consecutive sequential annual cohorts of pregnant women from the Sarlahi district in southern Nepal. We randomised mothers 1:1 to receive seasonally recommended trivalent inactivated influenza vaccine or saline placebo in blocks of eight, stratified by gestational age at enrolment (17-25 weeks vs 26-34 weeks). Women were eligible if they were married, 15-40 years of age, 17-34 weeks' gestation at enrolment, and

SUBMITTER: Steinhoff MC 

PROVIDER: S-EPMC5573632 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature