Amide-directed photoredox-catalysed C-C bond formation at unactivated sp³ C-H bonds.

ABSTRACT: Carbon-carbon (C-C) bond formation is paramount in the synthesis of biologically relevant molecules, modern synthetic materials and commodity chemicals such as fuels and lubricants. Traditionally, the presence of a functional group is required at the site of C-C bond formation. Strategies that allow C-C bond formation at inert carbon-hydrogen (C-H) bonds enable access to molecules that would otherwise be inaccessible and the development of more efficient syntheses of complex molecules. Here we report a method for the formation of C-C bonds by directed cleavage of traditionally non-reactive C-H bonds and their subsequent coupling with readily available alkenes. Our methodology allows for amide-directed selective C-C bond formation at unactivated sp³ C-H bonds in molecules that co

SUBMITTER: Chu JC 

PROVIDER: S-EPMC5574171 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature