Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort.

ABSTRACT:

Purpose

Genetic contributions to tinnitus have been difficult to determine due to the heterogeneity of the condition and its broad etiology. Here, we evaluated the genetic and nongenetic influences on self-reported tinnitus from the Swedish Twin Registry (STR).

Methods

Cross-sectional data from the STR was obtained. Casewise concordance rates (the risk of one twin being affected given that his/her twin partner has tinnitus) were compared for monozygotic (MZ) and dizygotic (DZ) twin pairs (N = 10,464 concordant and discordant twin pairs) and heritability coefficients (the proportion of the total variance attributable to genetic factors) were calculated using biometrical model fitting procedures.

Results

Stratification of tinnitus cases into subtypes according to latera

SUBMITTER: Maas IL 

PROVIDER: S-EPMC5589979 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature