Successful Use of [¹⁴C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism.

ABSTRACT:

Background

We previously showed the practical and ethical feasibility of using [¹⁴C]-microdosing for pharmacokinetic studies in children. We now aimed to show that this approach can be used to elucidate developmental changes in drug metabolism, more specifically, glucuronidation and sulfation, using [¹⁴C]paracetamol (AAP).

Methods

Infants admitted to the intensive care unit received a single oral [¹⁴C]AAP microdose while receiving intravenous therapeutic AAP every 6 h. [¹⁴C]AAP pharmacokinetic parameters were estimated. [¹⁴C]AAP and metabolites were measured with accelerator mass spectrometry. The plasma area under the concentration-time curve from time zero to infinity and urinary recovery ratios were related to age as

SUBMITTER: Mooij MG 

PROVIDER: S-EPMC5591809 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature