Microtopographical cues promote peripheral nerve regeneration via transient mTORC2 activation.

ABSTRACT: Despite microsurgical repair, recovery of function following peripheral nerve injury is slow and often incomplete. Outcomes could be improved by an increased understanding of the molecular biology of regeneration and by translation of experimental bioengineering strategies. Topographical cues have been shown to be powerful regulators of the rate and directionality of neurite regeneration, and in this study we investigated the downstream molecular effects of linear micropatterned structures in an organotypic explant model. Linear topographical cues enhanced neurite outgrowth and our results demonstrated that the mTOR pathway is important in regulating these responses. mTOR gene expression peaked between 48 and 72h, coincident with the onset of rapid neurite outgrowth and glial migration, an

SUBMITTER: Thomson SE 

PROVIDER: S-EPMC5593812 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature