The influence of analgesic-based sedation protocols on delirium and outcomes in critically ill patients: A randomized controlled trial.

ABSTRACT:

Objective

To investigate the influence of analgesic-based midazolam sedation on delirium and outcomes in critically ill patients and to analyze the risk factors of delirium.

Design

Single center, prospective randomized controlled trial.

Setting

A surgical intensive care unit (ICU) in a tertiary care hospital in China.

Patients

Mechanically ventilated patients requiring sedation.

Measurements and main results

Patients admitted to the surgical intensive care unit who required sedation and were undergoing mechanical ventilation for longer than 24 hours were randomly divided into three groups: 1) the remifentanil group received remifentanil and midazolam, 2) the fentanyl group received fentanyl and midazolam, and 3) the control group received only midazolam.

SUBMITTER: Liu D 

PROVIDER: S-EPMC5598969 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature