Ontology highlight
ABSTRACT:
SUBMITTER: Roberts MN
PROVIDER: S-EPMC5609489 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Cell metabolism 20170901 3
Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physio ...[more]