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Riboflavin as an independent and accurate biomarker for adherence in a randomized double-blind and placebo-controlled clinical trial.

ABSTRACT: BACKGROUND:Medication adherence is critical for success of clinical trials. OBJECTIVE:To assess oral riboflavin is an adherence marker. METHODS:Riboflavin was incorporated into active treatment and placebo pills for a clinical trial lasting for 2 years. RESULTS:The accuracy (area under the receiver operating curve) of urinary riboflavin was 0.91 as a binary classifier of adherence, and was similar or better than for two active study ingredients daidzein (0.92) and genistein (0.87) (all p?

SUBMITTER: Ramanujam VS

PROVIDER: S-EPMC5613754 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Riboflavin as an independent and accurate biomarker for adherence in a randomized double-blind and placebo-controlled clinical trial.

Ramanujam V-M S VS Nayeem Fatima F Anderson Karl E KE Kuo Yong-Fang YF Chen Nai-Wei NW Ju Hyunsu H Lu Lee-Jane W LW

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20161223 6

<h4>Background</h4>Medication adherence is critical for success of clinical trials.<h4>Objective</h4>To assess oral riboflavin is an adherence marker.<h4>Methods</h4>Riboflavin was incorporated into active treatment and placebo pills for a clinical trial lasting for 2 years.<h4>Results</h4>The accuracy (area under the receiver operating curve) of urinary riboflavin was 0.91 as a binary classifier of adherence, and was similar or better than for two active study ingredients daidzein (0.92) and ge ...[more]

PMID: 27918196

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