Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death.
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ABSTRACT:
SUBMITTER: de Andrade Mello P
PROVIDER: S-EPMC5620171 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death.
de Andrade Mello Paola P Bian Shu S Savio Luiz Eduardo Baggio LEB Zhang Haohai H Zhang Jingping J Junger Wolfgang W Wink Márcia Rosângela MR Lenz Guido G Buffon Andréia A Wu Yan Y Robson Simon Christopher SC
Oncotarget 20170621 40
Extracellular ATP (eATP) accumulation within the tumor microenvironment (TME) has the potential to activate purinergic signaling. The eATP evoked signaling effects bolster antitumor immune responses while exerting direct cytotoxicity on tumor cells and vascular endothelial cells, mediated at least in part through P2X7 receptors. Approaches to augment purinergic signaling in TME e.g. by ectonucleotidase CD39 blockade, and/or boosting P2X7 functional responses, might be used as immunomodulatory th ...[more]
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