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An increased rate of fracture occurs a decade earlier in HIV+ compared with HIV- men.

ABSTRACT: OBJECTIVES:To determine the incidence of fracture among aging HIV-infected (HIV+) and uninfected men (HIV-). To evaluate factors independently associated with fracture risk. DESIGN:Prospective, multicenter cohort study of men with or at risk for HIV. METHODS:Outcome measures: all fractures (excluding skull, face and digits) and fragility fractures (vertebral column, femur, wrist and humerus) were collected semiannually in 1221 HIV+ and 1408 HIV- men aged at least 40. Adjusted incident rate ratios (aIRR) with an interaction term for age (40-49, 50-59 and ?60 years) and HIV serostatus were estimated with Poisson regression models accounting for additional risk factors. RESULTS:Fracture incidence increased with age among both HIV+ and HIV- men. Although there was no significant difference in fracture incidence by HIV serostatus among men aged 40-49 years, the HIV+ men aged 50-59 years had a significantly higher incidence of all fractures [aIRR: 2.06 (1.49, 2.84)] and fragility fractures [aIRR: 2.06 (1.21, 3.50)] compared with HIV- participants of similar age. HIV modified the effect of age on all fractures (P?=?0.002) but did not significantly modify the effect for fragility fractures (P?=?0.135). Hypertension increased the rate of all fractures by 32% after adjustment for covariates [aIRR: 1.32 (1.04, 1.69)]. CONCLUSION:Fracture incidence increased with age among HIV+ and HIV- men but was higher among HIV+ men. A significant increase in fracture incidence was found among 50-59-year-old HIV+ men, highlighting the importance of osteoporosis screening for HIV-infected men above the age of 50.

SUBMITTER: Gonciulea A

PROVIDER: S-EPMC5624823 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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An increased rate of fracture occurs a decade earlier in HIV+ compared with HIV- men.

Gonciulea Anda A Wang Ruibin R Althoff Keri N KN Palella Frank J FJ Lake Jordan J Kingsley Lawrence A LA Brown Todd T TT

AIDS (London, England) 20170601 10

<h4>Objectives</h4>To determine the incidence of fracture among aging HIV-infected (HIV+) and uninfected men (HIV-). To evaluate factors independently associated with fracture risk.<h4>Design</h4>Prospective, multicenter cohort study of men with or at risk for HIV.<h4>Methods</h4>Outcome measures: all fractures (excluding skull, face and digits) and fragility fractures (vertebral column, femur, wrist and humerus) were collected semiannually in 1221 HIV+ and 1408 HIV- men aged at least 40. Adjust ...[more]

PMID: 28574962

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An increased rate of fracture occurs a decade earlier in HIV+ compared with HIV- men.

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An increased rate of fracture occurs a decade earlier in HIV+ compared with HIV- men.

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