An increased rate of fracture occurs a decade earlier in HIV+ compared with HIV- men.

ABSTRACT:

Objectives

To determine the incidence of fracture among aging HIV-infected (HIV+) and uninfected men (HIV-). To evaluate factors independently associated with fracture risk.

Design

Prospective, multicenter cohort study of men with or at risk for HIV.

Methods

Outcome measures: all fractures (excluding skull, face and digits) and fragility fractures (vertebral column, femur, wrist and humerus) were collected semiannually in 1221 HIV+ and 1408 HIV- men aged at least 40. Adjusted incident rate ratios (aIRR) with an interaction term for age (40-49, 50-59 and ≥60 years) and HIV serostatus were estimated with Poisson regression models accounting for additional risk factors.

Results

Fracture incidence increased with age among both HIV+ and HIV- men. Although there was

SUBMITTER: Gonciulea A 

PROVIDER: S-EPMC5624823 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature