Ontology highlight
ABSTRACT:
SUBMITTER: Cato L
PROVIDER: S-EPMC5629025 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
eLife 20170810
Targeting the activation function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is an attractive therapeutic alternative to the current approaches to inhibit AR action in prostate cancer (PCa). Here we show that the AR AF-1 is bound by the cochaperone Bag-1L. Mutations in the AR interaction domain or loss of Bag-1L abrogate AR signaling and reduce PCa growth. Clinically, Bag-1L protein levels increase with progression to castration-resistant PCa (CRPC) and high levels o ...[more]