Correction of collimator-dependent differences in the heart-to-mediastinum ratio in ¹²³I-metaiodobenzylguanidine cardiac sympathetic imaging: Determination of conversion equations using point-source imaging.

ABSTRACT:

Background

Septal penetration causes collimator-dependent differences in the heart-to-mediastinum (H/M) ratio in ¹²³I-metaiodobenzylguanidine (MIBG) cardiac imaging. We investigated generally applicable methods to correct such differences.

Methods and results

Four hours after ¹²³I-MIBG injection, 40 patients underwent anterior chest imaging successively with medium-energy (ME) and various non-ME collimators. The H/M ratios obtained with the non-ME collimators before and after ¹²³I-dual-window penetration correction were compared with the ME-derived standard values to determine patient-based conversion equations for empiric and combined corrections, respectively. A ¹²³I point source was imaged with various collimators, and the centr

SUBMITTER: Inoue Y 

PROVIDER: S-EPMC5629249 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature