Ontology highlight
ABSTRACT:
SUBMITTER: Bibert S
PROVIDER: S-EPMC5632961 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Frontiers in microbiology 20171004
Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue. The causative agent, <i>Mycobacterium ulcerans</i>, produces mycolactone, a macrolide toxin, which causes apoptosis of mammalian cells. Only a small proportion of individuals exposed to <i>M. ulcerans</i> develop clinical disease, as surrounding macrophages may control the infection by bacterial killing at an early stage, while mycolactone concentration is still low. Otherwise, bacterial multiplication le ...[more]