Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors.

ABSTRACT:

Objective

Obesity-associated WAT inflammation is characterized by the accumulation and local activation of macrophages (MΦs), and recent data from mouse studies suggest that macrophages are modifiers of adipocyte energy metabolism and mitochondrial function. As mitochondrial dysfunction has been associated with obesity and the metabolic syndrome in humans, herein we aimed to delineate how human macrophages may affect energy metabolism of white adipocytes.

Methods

Human adipose tissue gene expression analysis for markers of macrophage activation and tissue inflammation (CD11c, CD40, CD163, CD206, CD80, MCP1, TNFα) in relationship to mitochondrial complex I (NDUFB8) and complex III (UQCRC2) was performed on subcutaneous WAT of 24 women (BMI 20-61 kg/m²). Guided by t

SUBMITTER: Keuper M 

PROVIDER: S-EPMC5641636 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature