Room temperature C(sp²)-H oxidative chlorination via photoredox catalysis.

ABSTRACT: Photoredox catalysis has been developed to achieve oxidative C-H chlorination of aromatic compounds using NaCl as the chlorine source and Na₂S₂O₈ as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp²)-H bonds over C(sp³)-H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key intermediates to bioactive compounds and a drug.

SUBMITTER: Zhang L 

PROVIDER: S-EPMC5642143 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature