WciG O-Acetyltransferase Functionality Differentiates Pneumococcal Serotypes 35C and 42.

ABSTRACT: Streptococcus pneumoniae expresses capsular polysaccharides (CPSs) to protect itself from opsonophagocytic killing. The genes responsible for capsules synthesized by the Wzy-dependent mechanism, which accounts for 96 of the 98 known pneumococcal capsule types, are in a chromosomal region known as the cps locus. The nucleotide sequence in this region has been determined for all serotypes. In contrast, not all CPS structures have been defined. The structure of the serotype 35C polysaccharide was recently reported, but the presence of O-acetyltransferase genes in the serotype 35C cps locus suggested that it could be incomplete, as the reported structure contains no O-acetylation. In addition, the genetic distinction of serotype 35C from the closely related serotype

SUBMITTER: Geno KA 

PROVIDER: S-EPMC5648713 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature