Staphylococcus aureus interaction with Pseudomonas aeruginosa biofilm enhances tobramycin resistance.

ABSTRACT: Antimicrobial resistance is a significant threat to the treatment of infectious disease. Multiple mechanisms of resistance to different classes of antibiotics have been identified and well-studied. However, these mechanisms are studied with bacteria in isolation, whereas often, infections have a polymicrobial basis. Using a biofilm slide chamber model, we visualized the formation and development of clinical Pseudomonas aeruginosa biofilms in the presence of secreted Staphylococcus aureus exoproducts, two bacteria that commonly co-infect pediatric patients with cystic fibrosis. We showed that, over time, certain isolates of P. aeruginosa can form different biofilm architecture in the presence of S. aureus exoproducts. We further determined that this interaction w

SUBMITTER: Beaudoin T 

PROVIDER: S-EPMC5648753 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature