Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin.

ABSTRACT:

Background

Type 2 innate lymphoid cells (ILC2s) represent an important type 2 immune cell. Glucocorticoid regulation of human ILC2s is largely unknown.

Objective

We sought to assess steroid resistance of human blood and airway ILC2s from asthmatic patients and to examine its mechanism of induction.

Methods

We studied human blood and lung ILC2s from asthmatic patients and control subjects using flow cytometry and ELISA.

Results

Dexamethasone inhibited (P = .04) chemoattractant receptor-homologous molecule expressed on T_H2 lymphocytes and type 2 cytokine expression by blood ILC2s stimulated with IL-25 and IL-33. However, it did not do so when ILC2s were stimulated with IL-7 and thymic stromal lymphopoietin (TSLP), 2 ligands of IL-7 receptor α. Unlike b

SUBMITTER: Liu S 

PROVIDER: S-EPMC5650571 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature