Ontology highlight
ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC5651981 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nature 20170524 7656
Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances ther ...[more]