Impact of prior therapies on everolimus activity: an exploratory analysis of RADIANT-4.

ABSTRACT:

Background

Recently, everolimus was shown to improve median progression-free survival (PFS) by 7.1 months in patients with advanced, progressive, well-differentiated, nonfunctional neuroendocrine tumors (NET) of lung or gastrointestinal (GI) tract compared with placebo (HR, 0.48; 95% CI, 0.35-0.67; P<0.00001) in the Phase III, RADIANT-4 study. This post hoc analysis evaluates the impact of prior therapies (somatostatin analogs [SSA], chemotherapy, and radiotherapy) on everolimus activity.

Trial registration

ClinicalTrials.gov identifier: NCT01524783.

Patients and methods

Patients were randomized (2:1) to everolimus 10 mg/day or placebo, both with best supportive care. Subgroups of patients who received prior SSA, chemotherapy, or radiotherapy (including peptide

SUBMITTER: Buzzoni R 

PROVIDER: S-EPMC5652899 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature