Individual and combined effects of cannabis and tobacco on drug reward processing in non-dependent users.

ABSTRACT:

Rationale

Cannabis and tobacco are often smoked simultaneously in joints, and this practice may increase the risks of developing tobacco and/or cannabis use disorders. Currently, there is no human experimental research on how these drugs interact on addiction-related measures.

Objectives

This study aimed to investigate how cannabis and tobacco, each alone and combined together in joints, affected individuals' demand for cannabis puffs and cigarettes, explicit liking of drug and non-drug-related stimuli and craving.

Method

A double-blind, 2 (active cannabis, placebo cannabis) × 2 (active tobacco, placebo tobacco) crossover design was used with 24 non-dependent cannabis and tobacco smokers. They completed a pleasantness rating task (PRT), a marijuana purchase task (MPT)

SUBMITTER: Hindocha C 

PROVIDER: S-EPMC5660839 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature