Ontology highlight
ABSTRACT:
SUBMITTER: Liu JA
PROVIDER: S-EPMC5662599 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Nature communications 20171030 1
Following epithelial-mesenchymal transition, acquisition of avian trunk neural crest cell (NCC) polarity is prerequisite for directional delamination and migration, which in turn is essential for peripheral nervous system development. However, how this cell polarization is established and regulated remains unknown. Here we demonstrate that, using the RHOA biosensor in vivo and in vitro, the initiation of NCC polarization is accompanied by highly activated RHOA in the cytoplasm at the cell rear a ...[more]