Ontology highlight
ABSTRACT:
SUBMITTER: Wu L
PROVIDER: S-EPMC5662816 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Gastroenterology research and practice 20171016
<h4>Background</h4>Hepatic ischemia reperfusion (IR) injury is a common phenomenon in transplantation or trauma. The aim of the present study was to determine the protective effect of quercetin (QE) on hepatic IR injury via the ERK/NF-<i>κ</i>B pathway.<h4>Methods</h4>Mice were randomized into the sham, IR, QE100 + IR, and QE200 + IR groups. Quercetin was administered intragastrically daily at two doses (100 mg/kg and 200 mg/kg) for 5 days prior to IR injury. The expression levels of liver enzym ...[more]