Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy.

ABSTRACT: The mitochondrial Ca²⁺ uniporter complex (MCUC) is a multimeric ion channel which, by tuning Ca²⁺ influx into the mitochondrial matrix, finely regulates metabolic energy production. In the heart, this dynamic control of mitochondrial Ca²⁺ uptake is fundamental for cardiomyocytes to adapt to either physiologic or pathologic stresses. Mitochondrial calcium uniporter (MCU), which is the core channel subunit of MCUC, has been shown to play a critical role in the response to β-adrenoreceptor stimulation occurring during acute exercise. The molecular mechanisms underlying the regulation of MCU, in conditions requiring chronic increase in energy production, such as physiologic or pathologic cardiac growth, remain elusive. Here, we show that microRNA-1 (miR-1), a m

SUBMITTER: Zaglia T 

PROVIDER: S-EPMC5664523 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature