Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.

ABSTRACT: Comparative analyses of transcriptional profiles from humans and mice with cardiovascular pathologies revealed consistently elevated expression of MICU2, a regulatory subunit of the mitochondrial calcium uniporter complex. To determine if MICU2 expression was cardioprotective, we produced and characterized Micu2^-/- mice. Mutant mice had left atrial enlargement and Micu2^-/- cardiomyocytes had delayed sarcomere relaxation and cytosolic calcium reuptake kinetics, indicating diastolic dysfunction. RNA sequencing (RNA-seq) of Micu2^-/- ventricular tissues revealed markedly reduced transcripts encoding the apelin receptor (Micu2^-/- vs. wild type, P = 7.8 × 10^-40), wh

SUBMITTER: Bick AG 

PROVIDER: S-EPMC5664535 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature