Anti-Mullerian hormone and endometrial cancer: a multi-cohort study.

ABSTRACT:

Background

The Mullerian ducts are the embryological precursors of the female reproductive tract, including the uterus; anti-Mullerian hormone (AMH) has a key role in the regulation of foetal sexual differentiation. Anti-Mullerian hormone inhibits endometrial tumour growth in experimental models by stimulating apoptosis and cell cycle arrest. To date, there are no prospective epidemiologic data on circulating AMH and endometrial cancer risk.

Methods

We investigated this association among women premenopausal at blood collection in a multicohort study including participants from eight studies located in the United States, Europe, and China. We identified 329 endometrial cancer cases and 339 matched controls. Anti-Mullerian hormone concentrations in blood were quantified using

SUBMITTER: Fortner RT 

PROVIDER: S-EPMC5672934 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature