Prognostic factors and survival outcomes in patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era: Cohort study of 477 patients.

ABSTRACT:

Background

Outcomes in patients with chronic myeloid leukemia in blast phase (CML-BP) are historically dismal. Herein, the authors sought to analyze the characteristics, prognostic factors, and survival outcomes in patients with CML-BP in the tyrosine kinase inhibitor (TKI) era.

Methods

A total of 477 patients with CML-BP were treated with a TKI at some point during the course of their CML. Cox proportional hazard models identified characteristics that were predictive of survival. Overall survival and failure-free survival were assessed. Optimal cutoff points for specific parameters were identified using classification and regression tree (CART) analysis.

Results

The median age of the patients was 53 years (range, 16-84 years) and 64% were male. Approximately 80% of p

SUBMITTER: Jain P 

PROVIDER: S-EPMC5673547 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature