Trends in rates of acetaminophen-related adverse events in the United States.

ABSTRACT:

Purpose

The goal of this study is to summarize trends in rates of adverse events attributable to acetaminophen use, including hepatotoxicity and mortality.

Methods

A comprehensive analysis of data from three national surveillance systems estimated rates of acetaminophen-related events identified in different settings, including calls to poison centers (2008-2012), emergency department visits (2004-2012), and inpatient hospitalizations (1998-2011). Rates of acetaminophen-related events were calculated per setting, census population, and distributed drug units.

Results

Rates of poison center calls with acetaminophen-related exposures decreased from 49.5/1000 calls in 2009 to 43.5/1000 calls in 2012. Rates of emergency department visits for unintentional acetaminophen-re

SUBMITTER: Major JM 

PROVIDER: S-EPMC5676300 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature