Single cell transcriptomics suggest that human adipocyte progenitor cells constitute a homogeneous cell population.

ABSTRACT: Regulation of adipose tissue stem cells (ASCs) and adipogenesis impact the development of excess body fat-related metabolic complications. Animal studies have suggested the presence of distinct subtypes of ASCs with different differentiation properties. In addition, ASCs are becoming the biggest source of mesenchymal stem cells used in therapies, which requires deep characterization. Using unbiased single cell transcriptomics we aimed to characterize ASC populations in human subcutaneous white adipose tissue (scWAT). The transcriptomes of 574 single cells from the WAT total stroma vascular fraction (SVF) of four healthy women were analyzed by clustering and t-distributed stochastic neighbor embedding visualization. The identified cell populations were then mapped to cell types present in W

SUBMITTER: Acosta JR 

PROVIDER: S-EPMC5678572 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature