A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes.

ABSTRACT: The ability to integrate experiential information and recall it in the form of memory is observed in a wide range of taxa, and is a hallmark of highly derived nervous systems. Storage of past experiences is critical for adaptive behaviors that anticipate both adverse and positive environmental factors. The process of memory formation and consolidation involve many synchronized biological events including gene transcription, protein modification, and intracellular trafficking: However, many of these molecular mechanisms remain illusive. With Drosophila as a model system we use a nonassociative memory paradigm and a systems level approach to uncover novel transcriptional patterns. RNA sequencing of Drosophila heads during and after memory formation identified a number of novel memory genes.

SUBMITTER: Bozler J 

PROVIDER: S-EPMC5679645 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature