The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model.
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ABSTRACT:
SUBMITTER: Yamazaki R
PROVIDER: S-EPMC5686158 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model.
Yamazaki Risa R Yamazoe Katsuya K Yoshida Satoru S Hatou Shin S Inagaki Emi E Okano Hideyuki H Tsubota Kazuo K Shimmura Shigeto S
Scientific reports 20171114 1
Dry eye disease (DED) is a common disorder causing discomfort and ocular fatigue. Corneal nerves are compromised in DED, which may further cause loss of corneal sensation and decreased tear secretion. Semaphorin 3A (Sema3A) is expressed by the corneal epithelium under stress, and is known as an inhibitor of axonal regeneration. Using a murine dry eye model, we found that topical SM-345431, a selective Sema3A inhibitor, preserved corneal sensitivity (2.3 ± 0.3 mm versus 1.4 ± 0.1 mm in vehicle co ...[more]
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