Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis.

ABSTRACT:

Introduction

Telomeres, are composed of tandem repeat sequences located at the ends of chromosomes and are required to maintain genomic stability. Telomeres can become shorter due to cell division and specific lifestyle factors. Critically shortened telomeres are linked to cellular dysfunction, senescence and aging. A number of studies have used low resolution techniques to assess telomere length in the placenta. In this study, we applied Single Telomere Length Analysis (STELA) which provides high-resolution chromosome specific telomere length profiles to ask whether we could obtain more detailed information on the length of individual telomeres in the placenta.

Methods

Term placentas (37-42 weeks) were collected from women delivering at University Hospital of Wales or Royal

SUBMITTER: Garcia-Martin I 

PROVIDER: S-EPMC5687939 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature