Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis.

ABSTRACT: Compared with males, females have lower BP before age 60, blunted hypertensive response to angiotensin II, and a leftward shift in pressure natriuresis. This study tested the concept that this female advantage associates with a distinct sexual dimorphic pattern of transporters along the nephron. We applied quantitative immunoblotting to generate profiles of transporters, channels, claudins, and selected regulators in both sexes and assessed the physiologic consequences of the differences. In rats, females excreted a saline load more rapidly than males did. Compared with the proximal tubule of males, the proximal tubule of females had greater phosphorylation of Na⁺/H⁺ exchanger isoform 3 (NHE3), distribution of NHE3 at the base of the microvilli, and less abundant expr

SUBMITTER: Veiras LC 

PROVIDER: S-EPMC5698077 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature