The corepressor NCOR1 regulates the survival of single-positive thymocytes.

ABSTRACT: Nuclear receptor corepressor 1 (NCOR1) is a transcriptional regulator bridging repressive chromatin modifying enzymes with transcription factors. NCOR1 regulates many biological processes, however its role in T cells is not known. Here we show that Cd4-Cre-mediated deletion of NCOR1 (NCOR1 cKO^Cd4) resulted in a reduction of peripheral T cell numbers due to a decrease in single-positive (SP) thymocytes. In contrast, double-positive (DP) thymocyte numbers were not affected in the absence of NCOR1. The reduction in SP cells was due to diminished survival of NCOR1-null postselection TCRβ^hiCD69⁺ and mature TCRβ^hiCD69^- thymocytes. NCOR1-null thymocytes expressed elevated levels of the pro-apoptotic factor BIM and showed a higher fraction of

SUBMITTER: Muller L 

PROVIDER: S-EPMC5698297 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature