Ontology highlight
ABSTRACT:
SUBMITTER: Mikheikin A
PROVIDER: S-EPMC5698298 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171121 1
Progress in whole-genome sequencing using short-read (e.g., <150 bp), next-generation sequencing technologies has reinvigorated interest in high-resolution physical mapping to fill technical gaps that are not well addressed by sequencing. Here, we report two technical advances in DNA nanotechnology and single-molecule genomics: (1) we describe a labeling technique (CRISPR-Cas9 nanoparticles) for high-speed AFM-based physical mapping of DNA and (2) the first successful demonstration of using DVD ...[more]