Cytokine and autoantibody clusters interaction in systemic lupus erythematosus.

ABSTRACT:

Background

Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine. Therefore, the relationship between autoantibody and cytokine clusters in SLE was analyzed.

Methods

This was an exploratory study in which 67 consecutive women with established SLE were assessed. Clinical characteristics including disease activity, a 14-autoantibody profile,

SUBMITTER: Pacheco Y 

PROVIDER: S-EPMC5702157 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature